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应国光

应国光

  • 职称:天津市肿瘤研究所副所长

             肿瘤细胞生物实验室主任

             天津市肿瘤防治重点实验室主任

             教授,博士生导师

特长
肿瘤中的生物学作用和临床应用转化意义
详细介绍

      学历学位:

      1981.08-1986.07 理学士,清华大学化学系,北京

      1996.01-2000.12 科学博士,都灵大学医学院,都灵,意大利

      历任职位:

      1986.08-1992.10 研究实习员,卫生部上海生物制品研究所,国家科委国家基因工程生物制品联合研究开发中心

      1992.11-1995.12 访问学者,意大利都林大学医学院微生物与公共卫生系分子病毒学实验室

      1996.01-1999.12 Visiting Scientist,米兰Mario Negri药理研究所免疫及细胞生物学部

      2000.01-2001.06 博士后,都林大学医学院微生物与公共卫生系分子病毒学实验室

      2001.07-2003.06 博士后,美国国家癌症研究所分子免疫调节实验室

      2003.07-2007.08 Michel Arthur Fellow, 美国西北大学医学院 ENH研究所分子肿瘤学部

      2007.09- 教授,博士生导师,天津医科大学附属肿瘤医院,天津市肿瘤研究所,肿瘤细胞生物学实验室;天津市肿瘤防治重点实验室

      主要奖励:

      1992 欧共体玛丽亚-居里奖学金

      1993 中国国家科技进步一等奖,人基因工程1干扰素的研制,主要研制者之一

      1995 中国国家科技进步二等奖,人基因工程γ干扰素的研制、中试生产及临床应用,主要研制者之一

      1995 卫生部科技进步一等奖,基因工程γ干扰素的研制、中试生产及临床应用,主要研制者之一

      2004 Michel Arthur Fellow,美国Michel Arthur乳腺癌基金会

      学术兼职:

      2009 中华医学会医学细胞生物学分会委员

      2010 中国抗癌协会病因学分会委员

      2010 中国抗癌协会肿瘤转移分会委员

      研究基金:

      2008.1-2010.12 EHD蛋白对ErbB受体的转运调控机制研究, 国家自然科学基金面上项目(30772528), 29万 (责任人)

      2008.1-2010.12 EHD介导的受体转运调控与乳腺癌的关系, 肿瘤医院科研启动基金, 30万(责任人)

      2009.10-2012.9 非激素依赖性前列腺癌的蛋白组学和分子靶向研究, 天津市科委CMM-天津合作基金, 30万 (第三)

      2010.1-2014.8 iCSCs侵袭和转移相关预警分子筛查及意义研究(肿瘤干细胞在恶性肿瘤发生发展中的作用及机理研究),国家973计划项目 (2010CB529405), 30万(骨干)

      2011.1-2013.12 膜转运调节蛋白EHD2的核功能及其影响乳腺病变的机制研究,国家自然科学基金面上项目(81072158), 37万(责任人)

      学术论文:

      Chen YZ, Chen Z, Gong YA, Ying G (2012) SUMOhydro: A Novel Method for the Prediction of Sumoylation Sites Based on Hydrophobic Properties. PLoS One 7: e39195.

      Duo J, Ying GG, Wang GW, Zhang L (2012) Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol Med Report 5: 1453-1456.

      Li H, Wu J, Ying G, Chen L, Lai L, Liu Z, Zhang N, Guo H (2012) J-4: a novel and typical preclinical anticancer drug targeting protein kinase C zeta. Anticancer Drugs 23: 691-697.

      Ding T, Ma Y, Li W, Liu X, Ying G, Fu L, Gu F (2011) Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells. Int J Oncol 38: 1521-1531.

      Duan L, Raja SM, Chen G, Virmani S, Williams SH, Clubb RJ, Mukhopadhyay C, Rainey MA, Ying G, Dimri M, Chen J, Reddi AL, Naramura M, Band V, Band H (2011) Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. J Biol Chem 286: 620-633.

      George M, Rainey MA, Naramura M, Foster KW, Holzapfel MS, Willoughby LL, Ying G, Goswami RM, Gurumurthy CB, Band V, Satchell SC, Band H (2011) Renal Thrombotic Microangiopathy in Mice with Combined Deletion of Endocytic Recycling Regulators EHD3 and EHD4. PLoS One 6: e17838.

      Ma Y, Wang B, Li W, Liu X, Wang J, Ding T, Zhang J, Ying G, Fu L, Gu F (2011) Intersectin1-s is involved in migration and invasion of human glioma cells. J Neurosci Res 89: 1079-1090.

      Wang B, Yang D, Sun B, Wei X, Guo H, Liu X, Ying G, Niu R, Zhang N, Ma Y (2011) An anti-tumor nanoparticle, [Gd@C82(OH)22]n, induces macrophage activation. J Nanosci Nanotechnol 11: 2321-2329.

      Chen K, Le Y, Liu Y, Gong W, Ying G, Huang J, Yoshimura T, Tessarollo L, Wang JM (2010) A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses. J Immunol 184: 3331-3335.

      Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H (2010) Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. J Biol Chem 285: 1555-1568.

      George M, Rainey MA, Naramura M, Ying G, Harms DW, Vitaterna MH, Doglio L, Crawford SE, Hess RA, Band V, Band H (2010) Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. Genesis 48: 328-342.

      Ma Y, Wang B, Li W, Ying G, Fu L, Niu R, Gu F (2010) Reduction of intersectin1-s induced apoptosis of human glioblastoma cells. Brain Res 1351: 222-228.

      Rainey MA, George M, Ying G, Akakura R, Burgess DJ, Siefker E, Bargar T, Doglio L, Crawford SE, Todd GL, Govindarajan V, Hess RA, Band V, Naramura M, Band H (2010) The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC Dev Biol 10: 37.

      Wu J, Zhang B, Wu M, Li H, Niu R, Ying G, Zhang N (2010) Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis. Invest New Drugs 28: 268-275.

      Guo H, Ma Y, Zhang B, Sun B, Niu R, Ying G, Zhang N (2009) Pivotal Advance: PKCzeta is required for migration of macrophages. J Leukoc Biol 85: 911-918.

      Liu Y, Wang J, Wu M, Wan W, Sun R, Yang D, Sun X, Ma D, Ying G, Zhang N (2009) Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol Cancer Res 7: 944-954.

      Zhang B, Ma Y, Guo H, Sun B, Niu R, Ying G, Zhang N (2009) Akt2 is required for macrophage chemotaxis. Eur J Immunol 39: 894-901.

      Zhang F, Zhang L, Zhang B, Wei X, Yang Y, Qi RZ, Ying G, Zhang N, Niu R (2009) Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. J Proteome Res 8: 5041-5047.

      George M, Ying G, Rainey MA, Solomon A, Parikh PT, Gao Q, Band V, Band H (2007) Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. BMC Cell Biol 8: 3.

      Reddi AL, Ying G, Duan L, Chen G, Dimri M, Douillard P, Druker BJ, Naramura M, Band V, Band H (2007) Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. J Biol Chem 282: 29336-29347.

      Ying G, Iribarren P, Zhou Y, Gong W, Zhang N, Yu ZX, Le Y, Cui Y, Wang JM (2004) Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J Immunol 172: 7078-7085.

      Iribarren P, Cui YH, Le Y, Ying G, Zhang X, Gong W, Wang JM (2003) IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinases. J Immunol 171: 5482-5488.

      Le Y, Cui Y, Ying G, Iribarren P, Wang JM (2003) The role of chemokine receptors in the promotion of viral infections. Contrib Microbiol 10: 210-231.

      De Andrea M, Ravotto M, Noris E, Ying GG, Gioia D, Azzimonti B, Gariglio M, Landolfo S (2002) The interferon-inducible gene, Ifi204, acquires malignant transformation capability upon mutation at the Rb-binding sites. FEBS Lett 515: 51-57.

      Le Y, Cui Y, Iribarren P, Ying G, Wang JM (2002) Manipulating chemoattractant and receptor genes. In Vivo 16: 1-23.

      Heckman CA, Mehew JW, Ying GG, Introna M, Golay J, Boxer LM (2000) A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells. J Biol Chem 275: 6499-6508.

      Ying GG, Proost P, van Damme J, Bruschi M, Introna M, Golay J (2000) Nucleolin, a novel partner for the Myb transcription factor family that regulates their activity. J Biol Chem 275: 4152-4158.

      Gariglio M, Ying GG, Hertel L, Gaboli M, Clerc RG, Landolfo S (1997) The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure. Exp Cell Res 236: 472-481.

      Golay J, Facchinetti V, Ying G, Introna M (1997) The A-myb transcription factor in neoplastic and normal B cells. Leuk Lymphoma 26: 271-279.

      Golay J, Broccoli V, Borleri GM, Erba E, Faretta M, Basilico L, Ying GG, Piccinini G, Shapiro LH, Lovric J, Nawrath M, Molling K, Rambaldi A, Introna M (1997) Redundant functions of B-Myb and c-Myb in differentiating myeloid cells. Cell Growth Differ 8: 1305-1316.

      Hertel L, Foresta P, Barbiero G, Ying GG, Bonelli G, Baccino FM, Landolfo S, Gariglio M (1997) Decreased expression of the high-mobility group protein T160 by antisense RNA impairs the growth of mouse fibroblasts. Biochimie 79: 717-723.

      Ying GG, Arsura M, Introna M, Golay J (1997) The DNA binding domain of the A-MYB transcription factor is responsible for its B cell-specific activity and binds to a B cell 110-kDa nuclear protein. J Biol Chem 272: 24921-24926.

      Gariglio M, Foresta P, Ying GG, Gaboli M, Lembo D, Landolfo S (1996) Host genotype controls the ability of the ISGF3 complex to activate transcription of IFN-inducible genes. J Cell Biochem 60: 83-94.

      Gariglio M, Gaboli M, Mana C, Ying GG, Gribaudo G, Cavallo R, Landolfo S (1994) Characterization of nuclear factors involved in 202 gene induction by interferon-alpha in murine leukemia cells. Eur J Biochem 221: 731-739.

      Gariglio M, Gaboli M, Mana C, Foresta P, Ying GG, Angeretti A, Lembo D, Landolfo S (1994) Characterization of nuclear factors involved in 202 gene induction by IFN-alpha, viruses or dsRNA in murine leukemia cells. New Microbiol 17: 259-267.

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