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主讲教师

王欣

王欣

  • 职称:天津医科大学附属肿瘤医院,乳腺一科,科副主任

             副教授

特长
乳腺科
详细介绍

      教育背景:

      2002-2005.2:博士后,瑞典隆德大学,医学临床实验系

      1996-2001:博士学位,瑞典隆德大学,医学微生物,皮肤及感染系

      1986-1991:医学学士学位,中国天津医科大学

      工作经历:

      2005.2-至今, 副教授,天津医科大学附属肿瘤医院,乳腺一科,科副主任,

      2002-2005, 博士后,瑞典隆德大学,临床实验系

      1996—2001, 博士,瑞典隆德大学,医学微生物,皮肤及感染系

      1994-1995, 访问学者,瑞典隆德大学,实验外科系

      1991-1994, 乳腺科医生,天津肿瘤医院

      荣誉及社会职务:

      天津医科大学新世纪人才

      天津医科大学优秀教师。

      《中华肿瘤防治杂志》编委

      《中国肿瘤临床》杂志英文版编委

      《The Breast》《Breast J》etc。审稿人

      天津市科技进步三等奖

      中国抗癌协会乳腺癌专业委员会青年委员

      教学和培养学生:

      参与天津医科大学研究生‘临床试验’授课2005

      参与天津医科大学留学生‘肿瘤学科’授课,自2006至今

      参与天津医科大学留学生‘康复医学’授课,自2008至今

      培养已毕业硕士研究生7名,正在培养研究生10名,自2006-至今

      参与培养博士生2名

      培养进修生多名

      个人能力:

      临床工作经验以及多年的学院科研工作经验使我熟悉病人处理、外科技术以及新科题开发。乳腺癌的早期诊断,乳腺功能外科和个体化治疗。擅长乳腺癌各种根治术、保乳手术、前哨淋巴结活检、微创术和乳管镜检查。具有科学思维方式、丰富的从计划、操作、到报告研究成果等一成套的工作经验。多次在国际性会议上口头发言。本人具有很强的适应力和领悟力,高度的敬业精神与团体精神,踏实肯干,与同事相处融洽,服从命令,尊重领导,喜欢有创意的完成工作。

      2007年获得天津市科学技术进步三等奖。(项目:肋间臂神经解剖生理学及在乳腺功能外科的应用, 2007JB-3-164-R3)。具有GCP资格,能主持临床试验。已完成天津市高等学校科技发展基金计划项目,CysLT1和CysLT2受体与乳腺癌相关性的研究,并已成果鉴定。承担国家自然科学基金,肿瘤生长抑制因子Rb通过控制能量代谢平衡调节细胞转化作用的机制研究(第二承担人)。《现代乳腺肿瘤学》副主译。

      工作经验:

      · 肿瘤外科临床

      · 重组蛋白和蛋白纯化技术(包括高压液相色谱仪)

      · 细菌基因学

      · 电泳及免疫吸附试验

      · 细胞培养和组织培养以及相关分子 生物学上应用,如细胞循环、凋亡及细胞因子的探测。

      · DNA和RNA的萃取及PCR等

      · 电子显微镜

      · 动物试验(包括动物伦理学)

      发表文章:

      (1) Yunwei Han, Zhihao Yu, Shaoyan Wen, Bin Zhang, Xuchen Cao, Xin Wang. Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer. Breast Cancer Res Treat 2012; 131:483–490. (通讯作者)

      (2) 马祥敏,崔文静,张矫,王欣. 老年人乳腺癌综合治疗研究进展. 中华老年医学杂志 2012;31(5):442-444. (通讯作者)

      (3) 韩芸蔚,常新忠,温绍艳,王欣。男性和女性乳腺癌临床病理特征的配对比较及生存分析. 中华内分泌外科杂志 2012;6(2):102-105。(通讯作者)

      (4) 韩芸蔚,王欣,张斌,温绍艳,刘伟,曹旭晨。新辅助化疗诱导的粒细胞减少症对乳腺癌预后的影响. 中华普通外科杂志 2011;8(26):651-654. (通讯作者)

      (5) 温绍艳,韩芸蔚,马祥敏,等.三阴性乳腺癌的钼靶影像学表现和临床病理特征 [J].中华肿瘤杂志,2012,34(4):291-295。(通讯作者)

      (6) 温绍艳,王欣,曹旭晨.新辅助化疗乳腺癌前哨淋巴结活检时机的选择问题 [J].中国肿瘤外科杂志,2012,4(2):108-111(通讯作者)

      (7) 韩芸蔚,温绍艳,刘伟,王欣。 乳腺癌新辅助化疗的临床评价进展. 中国肿瘤临床 2011;38(7):408-411. (通讯作者)

      (8) 刘伟,李越,赵颖,等.乳腺癌腋窝淋巴结B超检查特异性回顾性分析. 中国实用外科杂志 2011;31(1):96-99. (通讯作者)

      (9) 刘伟,韩芸蔚,温绍艳,等. 乳腺中央型及外周型乳头状瘤癌变的外科治疗 中国肿瘤临床,2011;38(10):574-577. (通讯作者)

      (10) Wang X,Zhao Y and Cao X. Clincal benefits of mastectomy on treatment of occult breast csrcinoms presenting axillary metastases. The Breast Journal 2010;16:32-37.(通讯作者)

      (11) 于治灏,李越,王欣.Angiomotin在乳腺癌中的研究进展.中华乳腺病杂志 2010;4:53-56.(通讯作者)

      (12) 李越,王欣,赵颖,葛洁,张斌,于治灏,宁连胜,曹旭晨.超声光散射乳腺成像诊断乳腺癌假阳性率分析.中国肿瘤临床.2010;37:704-6. (通讯作者)

      (13) 王欣,李越,赵颖,葛洁,张斌,宁连胜,曹旭晨.光学功能成像技术在乳腺癌早期诊断中的应用.中华乳腺病杂志 2009,3(4):42-45.

      (14) 李越,赵颖,张斌,葛洁,宁连胜,曹旭晨,于治灏,王欣.超声光散射乳腺成像诊断乳腺癌的临床价值.中华乳腺病杂志 2009,3(4):20-24.(通讯作者)

      (15) 李越,王欣,于治灏,赵颖,宁连胜,曹旭晨.乳腺Paget’s病的临床病理分析.中国肿瘤临床 2009,36(17):980-982. (通讯作者)

      (16) 李越,王欣 5-FU代谢酶基因型多态性与乳腺癌化疗敏感相关性研究的进展.中华肿瘤防治杂志 2009,16(15):1192-1195. (通讯作者)

      (17) 闫哲,王欣. Cystatins与肿瘤发生发展关系的研究现状。中华乳腺病杂志2008;2(5):47-51.(通讯作者)

      (18) 王欣,闫哲,李晓青,冯玉梅和曹旭晨。Cystatin M在乳腺癌及转移癌中的表达和临床意义。中华乳腺病杂志2008;2(3):21-25.

      (19) Wang X and Ning L. Breast carcinoma associated with Poland’s syndrome: One case report and literatures. Chinese Journal of Clinical Oncology 2008;5(3): 223-225.

      (20) Wang X, Cao X and Ning L. Traumatic neuromas after mastectomy. ANS J Surg. 2007; 77:1.

      (21) 王欣,宁连胜. Poland综合征合并乳腺癌1例报道及文献回顾. 中国肿瘤临床 2008;35(2):78-79.

      (22) Wahlbom M, Wang X, Lindstr\x{00f6}m V, Carlemalm E, Jaskolski M and Grubb A. Fibrillogenic oligomers of human cystatin C are formed by propagated domain swapping. J Biol Chem. 2007;282(25):18318-26.

      (23) Wang X, Cao X and Ning L. Traumatic Neuromas in breast cancer patients after mastectomy. Chinese J of Clinical Oncology 2007;4(3):185-188.

      (24) Wang X. Presentation of Axillary Metastases from Occult Breast Carcinoma. Chinese J of Clinical Oncology 2007;4:1-5.

      (25) Selenica M, Wang X, Pedersen LO, Grubb A and Westlind-Danielsson A. Cystatin C Reduces the Formation of Soluble Ab1-42 Oligomers and Protofibrils. Scand J Clin Lab Invest 2007;67(2):179-90.

      (26) Ning L, Wang X, Zhao K, et al. Anatomical study of intercostobrachial never in SD rat. Chinese J of Clinical Oncology 2006;3:118-121.

      (27) Rodziewicz-Motowidio, S, Wahlbom M, Wang X, et al. Checking the conformational stability of cystatin C and its L68Q variant by molecular dynamics studies: Why is the L68Q variant amyloidogenic? Journal of Structural Biology 2006;154(1):68-78.

      (28) Nilsson M, Wang X, Rodziewicz-Motowidlo S, et al. Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C - Use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C. JOURNAL OF BIOLOGICAL CHEMISTRY 279 (23): 24236-24245 JUN 4 2004 [共享第一作者](SCI收录)

      (29) Chen D, Zhao CM, Wang X, et al. Target for gene therapy of gastric cancer: Gastrin? Helicobacter pylori infection may result in gastric cancer in hypergastrinemic mice but not in gastrin-deficient mice. CANCER GENE THERAPY 11 (12): 851-851 P6 DEC 2004 (SCI收录)

      (30) Zhao CM, Wang X, Friis-Hansen L, et al. Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient mice. REGULATORY PEPTIDES 115 (3): 161-170 OCT 15 2003. (SCI收录)

      (31) Liuba P, Pesonen E, Paakkari I, et al. Co-infection with Chlamydia pneumoniae and Helicobacter pylori results in vascular endothelial dysfunction and enhanced VCAM-1 expression in ApoE-knockout mice. JOURNAL OF VASCULAR RESEARCH 40 (2): 115-122 MAR-APR 2003. (SCI收录)

      (32) Wang X, Willen R, Svensson M, et al. Two-year follow-up of Helicobacter pylori infection in C57BL/6 and Balb/cA mice. APMIS 111 (4): 514-522 APR 2003 (SCI收录)

      (33) Chen D, Zhao CM, Wang X, et al. Disparate effects of chronic Helicobacter pylori infection on parietal cells and ECL cells in wild-type vs gastrin-deficient mice. INTERNATIONAL JOURNAL OF CANCER : 220-220 Suppl. 13 2002 (SCI收录)

      (34) Wang X: Helicobacter pylori infection in a mouse model: Development, optimization and inhibitory effects of antioxidants. Doctoral thesis, 2001, Department of Medical Microbiology, Dermatology and Infection, University of Lund, Lund, Sweden. (http://www.lub.lu.se/luft/diss/med558_transit.html)

      (35) Wang X, Hirmo S, Willén R, Wadstr\x{00f6}m T. Inhibition of Helicobacter pylori infection by bovine milk glycoconjugates in a BALB/cA mouse model. J Med Microbiol 2001; 50: 430-435. (SCI收录)

      (36) Wang X, Willen R, Wadstrom T: Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrob Agents Chemother 2000;44(9):2452-7. (SCI收录)

      (37) Wang X, Willen R, Andersson C, Wadstrom T: Development of high-grade lymphoma in Helicobacter pylori-infected C57BL/6 miceNote. Apmis 2000;108(7-8):503-508. (SCI收录)

      (38) Wang X, Sjunnesson H, Stureg\x{00e5}rd E, Wadstr\x{00f6}m T, Willén R and Aleljung P. Dietary factors influence the recovery rates of Helicobacter pylori in a BALB/cA mouse model. B&K Science Now 2000;9:1-6. (SCI收录)

      (39) Willen R, Carlen B, Wang X, Papadogiannakis N, Odselius R, Wadstrom T: Morphologic conversion of Helicobacter pylori from spiral to coccoid form. Scanning (SEM) and transmission electron microscopy (TEM) suggest viability. Ups J Med Sci 2000;105(1):31-40. (SCI收录)

      (40) Bennedsen M, Wang X, Willen R, Wadstrom T, Andersen LP: Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunol Lett 1999;70(3):185-9. (SCI收录)

      (41) Wang X, Sjunnesson H, Sturegard E, Wadstr\x{00f6}m T, Willén R, Aleljung P: Dietary factors influence the recovery rates of Helicobacter pylori in a BALB/cA mouse model. Zentralbl Bakteriol 1998;288(2):195-205. (SCI收录)

      (42) Wang X, Willén R, Wadstr\x{00f6}m T, Aleljung P: RAPD-PCR, histopathological and serological analysis of four mouse strains infected with multiple strains of Helicobacter pylori. Microbial Ecology in Health and Disease 1998;10:148-154. (SCI收录)

      (43) Wang X, Sturegard E, Rupar R, Nilsson HO, Aleljung PA, Carlén B, Willén R, Wadstr\x{00f6}m T: Infection of BALB/c A mice by spiral and coccoid forms of Helicobacter pylori. J Med Microbiol 1997;46(8):657-63. (SCI收录)

      (44) Aleljung P, Nilsson HO, Wang X, Nyberg P, Morner T, Warsame I, Wadstr\x{00f6}m T: Gastrointestinal colonisation of BALB/cA mice by Helicobacter pylori monitored by heparin magnetic separation. FEMS Immunol Med Microbiol 1996;13(4):303-9. (SCI收录)

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